Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus
نویسندگان
چکیده
منابع مشابه
Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus
BACKGROUND Modified function of immune cells in nasal secretions may play a role in the enhanced susceptibility to respiratory viruses that is seen in smokers. Innate immune cells in nasal secretions have largely been characterized by cellular differentials using morphologic criteria alone, which have successfully identified neutrophils as a significant cell population within nasal lavage fluid...
متن کاملEffect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study
BACKGROUND Smokers have increased susceptibility and altered innate host defense responses to influenza virus infection. Broccoli sprouts are a source of the Nrf2 activating agentsulforaphane, and short term ingestion of broccoli sprout homogenates (BSH) has been shown to reduce nasal inflammatory responses to oxidant pollutants. OBJECTIVES Assess the effects of BSH on nasal cytokines, virus ...
متن کاملCorrection: Effect of Broccoli Sprouts on Nasal Response to Live Attenuated Influenza Virus in Smokers: A Randomized, Double-Blind Study
Smokers HMOX1 ASH 2.44 (1.07, 4.90) 2.43 (1.07, 6.24) 2.11 (0.71, 6.86) 2.74 (0.97, 5.14) 1.73 (0.84, 3.82) BSH 2.73 (1.44, 3.13) 2.14 (1.49, 2.37) 2.83 (1.98, 3.93) 1.49 (1.27, 2.97) 2.05 (1.12, 3.27) NQO1 ASH 1.70 (0.82, 5.48) 2.33 (1.23, 5.32) 1.76 (0.67, 4.00) 1.47 (0.63, 5.15) 2.11 (0.91, 4.31) BSH 0.30 (0.14, 1.95) 1.29 (0.93, 2.34) 1.58 (1.01, 3.95) 0.90 (0.63, 3.33) 0.86 (0.32, 2.20) No...
متن کاملBoosted Influenza-Specific T Cell Responses after H5N1 Pandemic Live Attenuated Influenza Virus Vaccination
BACKGROUND In a phase I clinical trial, a H5N1 pandemic live attenuated influenza virus (pLAIV) VN2004 vaccine bearing avian influenza H5N1 hemagglutinin (HA) and NA genes on the A/Ann Arbor cold-adapted vaccine backbone displayed very restricted replication. We evaluated T cell responses to H5N1 pLAIV vaccination and assessed pre-existing T cell responses to determine whether they were associa...
متن کاملMolecular Basis of Live-Attenuated Influenza Virus
Human influenza is a seasonal disease associated with significant morbidity and mortality. The most effective means for controlling infection and thereby reducing morbidity and mortality is vaccination with a three inactivated influenza virus strains mixture, or by intranasal administration of a group of three different live attenuated influenza vaccine strains. Comparing to the inactivated vac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Respiratory Research
سال: 2011
ISSN: 1465-993X
DOI: 10.1186/1465-9921-12-102